Penicilloyl-Polylysine Stability and Clinical Use Over Time


 

Eric Macy, MD; CK Lin, PhD; Bruce Goldberg, MD, PhD

Fall 2007 - Volume 11 Number 4

https://doi.org/10.7812/TPP/07-063

Abstract

Background: The major penicillin skin test reagent, penicilloyl-polylysine, has not been commercially available since October 2004. The minimal concentration of penicilloyl-polylysine necessary for safe penicillin skin testing has not been determined.

Methods: Penicillin skin testing was performed on 596 individuals between October 2004 and October 2006 using out-of-date commercially produced penicilloyl-polylysine as part of a complete panel of reagents. The concentration of active penicilloyl-polylysine was measured. Outcomes were compared with those for 921 individuals tested between October 2002 and September 2004 using in-date commercially produced penicilloyl-polylysine.

Results: There was no significant difference in the fraction of patients who had positive skin test results using indate (5.1%) versus out-of-date (4.7%) penicilloyl-polylysine . There were four mild but no serious adverse reactions in the patients tested with the outdated reagent who were then challenged with oral penicillin class antibiotics.

Conclusion: Penicillin skin testing can be safely done using penicilloyl-polylysine down to a concentration of 4.29 × 10-5 M.

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