How Can We Manage Hyperlipidemia and Avoid Rhabdomyolysis in Transplant Patients?


Joseph M Kahwaji, MD, MPH; Ryszard R Dudek, MD

Fall 2006 - Volume 10 Number 3

Case Summary

A 25-year-old man with a history of perinuclear antineutrophil cytoplasmic antibodies-associated vasculitis presented to the ambulatory clinic with five days of diffuse myalgias and muscle tenderness. The patient had undergone kidney transplantation three years before presentation and had no post-transplant complications. He was maintained on cyclosporine, prednisone, and mycophenolate mofetil. Simvastatin 20mg daily was started two months after transplantation for development of post-transplant hyperlipidemia. Three months before presentation, the creatinine concentration was 1.8mg/dL. Two months before presentation, the simvastatin dosage was increased to 40 mg daily.


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