The Rural Inpatient Mortality Study: Does Urban-Rural County Classification Predict Hospital Mortality in California?

The Rural Inpatient Mortality Study: Does Urban-Rural County Classification Predict Hospital Mortality in California?

 

Daniel T Linnen, PhD(c), MS, RN-BC; John Kornak, PhD; Caroline Stephens, PhD, MS, RN, GNP

Perm J 2018;22:17-078 [Full Citation]

https://doi.org/10.7812/TPP/17-078
E-pub: 03/28/2018

ABSTRACT

Context: Evidence suggests an association between rurality and decreased life expectancy.
Objective: To determine whether rural hospitals have higher hospital mortality, given that very sick patients may be transferred to regional hospitals.
Design: In this ecologic study, we combined Medicare hospital mortality ratings (N = 1267) with US census data, critical access hospital classification, and National Center for Health Statistics urban-rural county classifications. Ratings included mortality for coronary artery bypass grafting, stroke, chronic obstructive pulmonary disease, heart attack, heart failure, and pneumonia across 277 California hospitals between July 2011 and June 2014. We used generalized estimating equations to evaluate the association of urban-rural county classifications on mortality ratings.
Main Outcome Measures: Unfavorable Medicare hospital mortality rating “worse than the national rate” compared with “better” or “same.”
Results: Compared with large central “metro” (metropolitan) counties, hospitals in medium-sized metro counties had 6.4 times the odds of rating “worse than the national rate” for hospital mortality (95% confidence interval = 2.8-14.8, p < 0.001). For hospitals in small metro counties, the odds of having such a rating were 3.7 times greater (95% confidence interval = 0.7-23.4, p = 0.12), although not statistically significant. Few ratings were provided for rural counties, and analysis of rural counties was underpowered.
Conclusion: Hospitals in medium-sized metro counties are associated with unfavorable Medicare mortality ratings, but current methods to assign mortality ratings may hinder fair comparisons. Patient transfers from rural locations to regional medical centers may contribute to these results, a potential factor that future research should examine.

INTRODUCTION

The health of rural populations is challenged by lower access to health care services and a wider geographic dispersion of health services compared with urban and suburban settings.1 The association between rurality and worse-than-average hospital mortality has been found in prior research.1-4 The US National Advisory Committee on Rural Health and Human Services also noted that rural mortality rates in the US were, on average, 13% higher compared with metropolitan areas and that the gap between the 2 regions is widening.4 Evidence suggests that rural patients have access to fewer hospitals and clinicians, and are exposed to long transfer times via ambulance or helicopter.5-9 Rural hospitals serving small communities have lower occupancy rates and are at increased risk of closure.10 Medicaid expansions under the Affordable Care Act11 have increased hospital profitability in some rural locations.7 However, many critical access hospitals (CAHs) must cope with substantial resource shortages, including limited access to clinicians and capital.12 Consequently, if rural hospitals lack the resources to care for very sick patients,6 transferring or diverting these patients to regional hospitals would reduce observable mortality in rural hospitals and increase it in the receiving hospitals. Hospital mortality ratings from Centers for Medicare and Medicaid Services (CMS) do not account for rurality and/or patient transfer patterns.13

It is difficult to define rurality in unambiguous terms. In some US states, rural communities may be situated next to small or medium-sized cities, which may facilitate more between-hospital transfers or direct admissions to adjacent regional hospitals. In other states, the entire population may be relatively isolated, and hospitals operate relatively independently. California, for example, has a highly developed agricultural sector, and many of its inland counties have an urbanized center. Consequently, there may be fewer isolated rural hospitals in this state than in other parts of the US. It is unclear whether the increased level of hospital mortality in rural areas seen throughout the US is evident in states such as California.

The aim of this study was to evaluate whether, and which, urban-rural county classifications are associated with hospital mortality in California. We hypothesized that CMS risk-adjusted hospital mortality ratings (worse, same, better than the national average) would be associated with counties’ urban-rural classification as defined using the National Center for Health Statistics (NCHS) 6-level classification scheme (from Class 1 to 6: Large central metro [metropolitan], large fringe metro, medium metro, small metro, micropolitan, noncore).14

METHODS

The institutional review board of the University of California, San Francisco determined that this study was exempt according to its human subjects protection guidelines. Data were publicly available, and we did not use patient data.

Study Design and Population

In this ecologic study, we evaluated the association of NCHS urban-rural county classifications with hospital mortality ratings, adjusting for mean county population age, county sex distributions, and CAH classification. We built the research dataset by joining CMS mortality ratings data with 2010 US Census Bureau data for median age, sex, county population size, and NCHS urban-rural county classifications.

The study population included 320 California hospitals that were given mortality ratings by CMS between July 2011 and June 2014. After excluding 43 hospitals that CMS coded as “not available” or “number of cases too small to report,” 277 hospitals remained in the study. CMS did not rate federal facilities, long-term care facilities, skilled nursing facilities, psychiatric institutions, or rehabilitation facilities in this dataset. California has 34 hospitals with CMS CAH designation, defined as ”hospitals with a maximum of 25 beds that are in a rural area over 35 miles from another hospital.”15 We did not identify patients for this study because this study did not require any patient-level data.

Measurements

Outcome Variable

The outcome variable was a CMS hospital mortality rating, coded as “worse” vs “the same or better” than the national rate. CMS analyzes and reports hospital-level, risk-adjusted 30-day mortality ratings for Medicare and Medicaid fee-for-service beneficiaries who received hospital care as inpatients using risk-standardized mortality rates (RSMRs).16 These RSMRs account for patient characteristics, including age, comorbidities, and frailty, using a complex algorithm.17 Then CMS classifies each hospital’s RSMR as better, the same as, or worse than the national rate.13 These ratings do not describe individual patients; rather, they summarize mortality for the following 6 patient populations: Coronary artery bypass graft, stroke, chronic obstructive pulmonary disease, acute myocardial infarction (heart attack), heart failure, and pneumonia. Throughout the study period, CMS rated each hospital only once per diagnosis. Thus, we obtained as many as 6 mortality ratings for each hospital.

Predictor Variables

The primary predictor was NCHS urban-rural classification14 measured at the county level (Table 1). We obtained county data on age and sex from the 2010 US Census and CAH designation data from a California Hospital Association 2016 public listing,15 coded as present or not present. The initial set of predictor variables included NCHS urban-rural county classification, median age and female-male ratio at the county level, and CAH classification at the hospital level.

Statistical Analysis

We performed data transformations and statistical modeling and testing in Stata 14 (StataCorp LLC, College Station, TX) as well as data joins, visual graphs, and maps in Tableau Desktop 9.1 (Tableau Software, Seattle, WA). We fit the initial model using stepwise forward addition of predictor variables. Variables were included if they met a statistical significance threshold of p < 0.05, and the predictor with the lowest p value was added first. This approach removed median age, female-male ratio, and CAH classification in the interest of parsimony, and retained the NCHS urban-rural county classifications. Hospital clustering accounted for possible dependence of ratings within hospitals. Inferences were based on robust standard errors incorporating hospital-level clustering using generalized estimating equation methods.18

On model fitting, a test for homogeneity confirmed within-group differences for the urban-rural county classifications (p < 0.001). Likelihood ratio testing between 2 models with and without the urban-rural county classification confirmed a significantly better model fit in the model with this predictor (c2 = 30.1, p < 0.001). Standardized Pearson residual plotting confirmed constant variance and the absence of influential points (data not shown). The Hosmer-Lemeshow statistic did not demonstrate a statistically significant lack of fit (p = 0.02).

The Rural Inpatient Mortality Study: Does Urban-Rural County Classification Predict Hospital Mortality in California?

RESULTS

Descriptive Statistics and Geographic Mapping

Among all mortality ratings, CMS reported 19% as “number of cases too small to report” and 16% as “not available.” These ratings were excluded. Table 2 summarizes characteristics of hospitals and counties in California by urban-rural county classification (n = 277). A total of 27 hospitals (9.8%) were in rural counties (NCHS Classes 5 and 6), compared with 250 hospitals (90.2%) in counties with at least one large/medium/small metro area (NCHS Classes 1 through 4). Of the 1267 CMS mortality ratings, 92 (7.3%) occurred in rural counties and 1175 ratings (92.7%) occurred in urban counties. The female-male ratio was approximately 1.0 across all counties. The counties’ mean population age ranged from 35.6 years in large metro counties to 45.2 years in the most rural settings. Of the 24 counties with CAHs, 16 (66.7%) were rurally classified (NCHS Class 5 or 6).

We compared mortality rating frequencies by medical diagnosis across NCHS urban-rural county classes (Table 3). Hospitals in large central metro counties and counties adjacent to large metro counties (NCHS Classes 1 and 2) accounted for all better-than-average mortality performance for stroke, chronic obstructive pulmonary disease, acute myocardial infarction, heart failure, and pneumonia. A large share of “worse than the national rate” ratings (58%) occurred in hospitals in medium-sized metro counties. None of the “worse than the national rate” ratings occurred in rural counties (Figure 1). The geographic map of CMS ratings (Figure 2) confirmed favorable hospital mortality ratings in the state’s 2 metropolitan hubs and a greater number of “worse than the national rate” mortality ratings in inland territory such as the San Joaquin Valley, the state’s largest agricultural area.

Modeling Results

Table 4 shows the results for the unadjusted and adjusted models. Compared with large central metros, the odds of a mortality rating “worse than the national rate” were 6.4 times greater for hospitals in medium-sized metro areas. (95% confidence interval [CI] = 2.8-14.8, p < 0.001). For hospitals in small metros, the odds of a “worse than the national rate” rating were 3.7 times greater compared with large central metros (95% CI = 0.7-23.4, p = 0.12). For hospitals in rural counties, outcome odds were essentially equal (odds ratio = 1.1), and CIs were wide (95% CI = 0.1-8.7, p = 0.92).

The Rural Inpatient Mortality Study: Does Urban-Rural County Classification Predict Hospital Mortality in California?

The Rural Inpatient Mortality Study: Does Urban-Rural County Classification Predict Hospital Mortality in California?

The Rural Inpatient Mortality Study: Does Urban-Rural County Classification Predict Hospital Mortality in California?

The Rural Inpatient Mortality Study: Does Urban-Rural County Classification Predict Hospital Mortality in California?

The Rural Inpatient Mortality Study: Does Urban-Rural County Classification Predict Hospital Mortality in California?

DISCUSSION

We sought to evaluate whether urban-rural county classifications are associated with hospital mortality in California. Before discussing the results, we wish to point out the study limitations. First, because of the ecologic design, we cannot establish causality for the observed association of “worse than the national rate” mortality ratings and medium-sized and small metro counties. Similarly, the ecologic design further limits our analysis to the macro level of counties in the state, not individual care encounters or hospitals. Second, CMS and other public databases do not report characteristics of hospitals with NCHS Classes 3 and 4 (hospital occupancy rates, services, clinician certifications), their patient characteristics (comorbidities, severity of illness, health behaviors, medication adherence), or process measures (transport from rural location, transport time, time from door to treatment). Our model does not adjust for these potential factors; however the CMS ratings do risk-adjust for patient characteristics, and the association between NCHS medium-sized metro counties and unfavorable hospital mortality ratings was quite strong. A third limitation is that power for rural counties was not adequate to detect an effect for rural hospitals because the number of “worse than the national rate” mortality ratings was small. To address this, we combined the 6 diagnosis-based mortality ratings into 1 outcome variable. An additional limitation is that NCHS urban-rural classes are measured at the county level. We observed one-third of CAHs in nonrural counties even though CAHs are defined as rural.15 This incongruence suggests that urbanized counties may still contain a substantial proportion of rural communities. A more granular measure of rurality may add more precision in future studies. Finally, generalizability is limited to US states and countries that are similar to California in size, economy, and urban-rural hospital distributions.

Policymakers appear to agree that rurality is associated with unfavorable hospital mortality. Our results, however, suggest that patients receiving hospital care in California’s small to medium-sized metro counties fare worse than those in rural counties and the main metropolitan regions of the state. The NCHS medium-sized metro counties had a very strong association with “worse than the national rate” mortality even after applying robust standard errors, which are the most resistant to incorrect modeling assumptions. Figure 2 shows two distinct regions of better-than-average mortality outcomes in the resource-rich metropolitan hubs of the state.

For urban metro counties, our findings agree with prior evidence regarding the impact of closer proximity to care, better clinician-to-population ratios, and overall better mortality trends in metropolitan settings described previously. Contrary to prior studies using national datasets, we did not detect increased hospital mortality in rural counties (or hospitals with critical access designation). The seemingly favorable mortality ratings for rural hospitals may be caused by their limited scope of services.19,20 These hospitals may not be equipped to handle critically ill patients3 and may transfer critically ill patients to the nearest regional medical centers.6 Accordingly, these transfer patterns may increase the pool of very ill patients in the receiving hospitals, which is then reflected in their unfavorable CMS mortality ratings. This explanation agrees with prior research that has found that patients in CAHs are generally healthier than those transferred to regional medical centers.19

The way rural hospitals are used in California seems to be working well, in that their hospital mortality rates are not keenly elevated. For medium-sized metropolitan counties, hospital mortality rates were strikingly elevated (although our study could not disentangle the many potential explanations for the elevated rates). Because rural hospitals may send acutely ill patients to larger hospitals (if they admit them in the first place), rating challenges may obscure federal quality ratings of hospital mortality. Results from this study suggest that CMS should account for patient transfer rates6 because overlooking contextual risk factors introduces unexplained variation in measurement.21 For example, “primary rural residence with transfer to a regional medical center” may be an important variable to quantify. Without this context, CMS may potentially penalize receiving hospitals in medium-sized metro counties in certain states for patient mortality outside their control. A second explanation for the higher risk of mortality in medium-sized metro counties is poorer population health. For example, California’s San Joaquin Valley is a large agricultural region within NCHS Classes 3 and 4. A 2016 population health report22 discussed the valley’s unique health challenges, including poor health of undocumented immigrants, drug abuse, asthma, obesity, poor dental health, and psychiatric illness. Exacerbating factors include social determinants of health, such as poverty and low educational attainment. CMS may not capture such population health disparities in medium-sized metro counties as root causes of mortality and, again, may inadvertently penalize hospitals in such communities.

Conclusion

Policymakers should continue to advocate for rural health initiatives, particularly those increasing access and services, but they should also consider whether the transferring of rural patients to nonrural or semirural regional hubs has an impact on these hospitals’ mortality performance. Future research should assess whether transfers skew hospital mortality data and should investigate what processes contribute to these patterns. Patient transfer time, time-to-treatment, patient-level health predictors, median income and other socioeconomic data, and utilization of outpatient services, such as hospice and home health, may be important explanatory variables for the observed increased hospital mortality in counties with medium-sized metros.

Disclosure Statement

The author(s) have no conflicts of interest to disclose.

Acknowledgments

Daniel Linnen, PhD(c), MS, RN-BC, would like to thank the University of California, San Francisco School of Medicine’s Training in Clinical Research Program and its faculty for providing a world-class exposure to biostatistics and epidemiology.

Kathleen Louden, ELS, of Louden Health Communications provided editorial assistance.

How to Cite this Article

Linnen DT, Kornak J, Stephens C. The Rural Inpatient Mortality Study: Does urban-rural county classification predict hospital mortality in California? Perm J 2018;22:17-078. DOI: https://doi.org/10.7812/TPP/17-078

References
1.    Institute of Medicine of the National Academies. Quality through collaboration: The future of rural health. Washington, DC: The National Academies Press; 2005. DOI: https://doi.org/10.17226/11140.
    2.    Joynt KE, Harris Y, Orav EJ, Jha AK. Quality of care and patient outcomes in critical access rural hospitals. JAMA 2011 Jul 6;306(1):45-52. DOI: https://doi.org/10.1001/jama.2011.902.
    3.    Joynt KE, Orav EJ, Jha AK. Mortality rates for medicare beneficiaries admitted to critical access and non-critical access hospitals, 2002-2010. JAMA 2013 Apr 3;309(13):1379-87. DOI: https://doi.org/10.1001/jama.2013.2366.
    4.    National Advisory Committee on Rural Health and Human Services. Mortality and life expectancy in rural America: Connecting the health and human service safety nets to improve health outcomes over the life course [Internet]. Rockville, MD: Health Resources and Services Administration; 2015 Oct [cited 2017 Nov 6]. Available from: www.hrsa.gov/advisorycommittees/rural/publications/mortality.pdf.
    5.    Barker AR, Londeree JK, McBride TD, Kemper LM, Mueller K; Rural Health Research & Policy Centers; RUPRI Center for Rural Health Policy Analysis, University of Iowa College of Public Health, Department of Health Management and Policy. The uninsured: An analysis by income and geography. Rural Policy Brief 2013 Jun 1;(2013 6):1-4.
    6.    Carr BG, Bowman AJ, Wolff CS, et al. Disparities in access to trauma care in the United States: A population-based analysis. Injury 2017 Feb;48(2):332-8. DOI: https://doi.org/10.1016/j.injury.2017.01.008.
    7.    Kaufman BG, Reiter KL, Pink GH, Holmes GM. Medicaid expansion affects rural and urban hospitals differently. Health Aff (Millwood) 2016 Sep 1;35(9):1665-72. DOI: https://doi.org/10.1377/hlthaff.2016.0357.
    8.    Rural Health Information Hub. Healthcare access in rural communities [Internet]. Washington, DC: US Department of Health and Human Services; 2014 Sep 8 [reviewed 2017 Jun 9; cited 2017 Nov 6]. Available from: www.ruralhealthinfo.org/topics/healthcare-access.
    9.    Office of Disease Prevention and Health Promotion. Healthy People 2020: Access to health services [Internet]. Washington, DC: US Department of Health and Human Services; 2016 [updated 2017 Nov 3; cited 2017 Nov 6]. Available from: www.healthypeople.gov/2020/leading-health-indicators/2020-lhi-topics/Access-to-Health-Services.
    10.    Kaufman BG, Thomas SR, Randolph RK, et al. The rising rate of rural hospital closures. J Rural Health 2016 Winter;32(1):35-43. DOI: https://doi.org/10.1111/jrh.12128.
    11.    The Patient Protection and Affordable Care Act of 2010. Public Law 111-148, 111th Congress, 124 Stat 119, HR 3590, enacted 2010 Mar 23.
    12.    Oberlin S, Thygesen B, Walters S. The financial health of California’s critical access hospitals [Internet]. Oakland, CA: California HealthCare Foundation; 2010 Feb [cited 2017 Nov 6]. Available from: www.chcf.org/~/media/MEDIA%20LIBRARY%20Files/PDF/PDF%20F/PDF%20FinancialHealthCriticalAccessHospitals.pdf.
    13.    Centers for Medicare & Medicaid Services (CMS). Frequently asked questions: Risk-standardized outcome and payment measures—Hospital Inpatient Quality Reporting (IQR) Program: Fiscal year 2018 [Internet]. Baltimore, MD: Centers for Medicare and Medicaid Services; 2016 [cited 2017 Nov 22]. Available from: www.ncqualitycenter.org/wp-content/uploads/2017/07/2017_CBM_FAQs.pdf.
    14.    Ingram DD, Franco SJ. NCHS urban-rural classification scheme for counties. Vital Health Statistics: Series 2, no. 154 [Internet]. Washington, DC: US Department of Health and Human Services; 2012 Jan [cited 2017 Nov 6]. Available from: www.cdc.gov/nchs/data/series/sr_02/sr02_154.pdf.
    15.    Critical access hospitals [Internet]. Sacramento, CA: California Hospital Association; c2017 [cited 2017 Nov 6]. Available from: www.calhospital.org/critical-access-hospitals.
    16.    Frequently asked questions (FAQs): Implementation and maintenance of CMS mortality measures for AMI & HF [Internet]. Baltimore, MD: Centers for Medicare and Medicaid Services; 2007 Jun 19 [cited 2017 Nov 6]. Available from: www.cms.gov/Medicare/Quality-Initiatives-Patient-Assessment-Instruments/HospitalQualityInits/downloads/HospitalMortalityAboutAMI_HF.pdf.
    17.    CMS’s 30-day risk-standardized mortality measures 2017 fact sheet [Internet]. Baltimore, MD: Centers for Medical and Medicaid Services QualityNet; 2016 [cited 2017 Nov 22]. Available from: www.qualitynet.org/dcs/BlobServer?blobkey=id&blobnocache=true&blobwhere=1228890668887&blobheader=multipart%2Foctet-stream&blobheadername1=Content-Disposition&blobheadervalue1=attachment%3Bfilename%3D2017_Mort_Msrs_FactSheet.pdf&blobcol=urldata&blobtable=MungoBlobs.
    18.    Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika 1986 Apr;73(1):13-22. DOI: https://doi.org/10.1093/biomet/73.1.13.
    19.    Ibrahim AM, Hughes TG, Thumma JR, Dimick JB. Association of hospital critical access status with surgical outcomes and expenditures among Medicare beneficiaries. JAMA 2016 May 17;315(19):2095-103. DOI: https://doi.org/10.1001/jama.2016.5618.
    20.    James PA, Li P, Ward MM. Myocardial infarction mortality in rural and urban hospitals: Rethinking measures of quality of care. Ann Fam Med 2007 Mar-Apr;5(2):105-11. DOI: https://doi.org/10.1370/afm.625.
    21.    Krumholz HM, Wang Y, Mattera JA, et al. An administrative claims model suitable for profiling hospital performance based on 30-day mortality rates among patients with heart failure. Circulation 2006 Apr 4;113(13):1693-701. DOI: https://doi.org/10.1161/circulationaha.105.611194.
    22.    Harder+Company Community Research. San Joaquin County 2016 community health needs assessment [Internet]. Stockton, CA: Healthier San Joaquin; 2016 [cited 2017 Nov 6]. Available from: http://healthiersanjoaquin.org/pdfs/2016/2016%20CHNA%20full%20document%20-%20narrative%20and%20health%20profiles.pdf.

Click here to join the E-TOC list or text TPJ to 22828. You will receive an Email notice with the Table of Contents of each issue.

The Permanente Journal

Sponsored by the eight Permanente Medical Groups, The Permanente Journal advances knowledge in scientific research, clinical medicine, and innovative health care delivery.

Reprint Permissions

The Permanente Journal welcomes requests for reprints and reproduction. Use of any and all material published in The Permanente Journal is copyrighted and protected.

The Permanente Press

The Permanente Press publishes The Permanente Journal and books related to healthcare. Journal subscriptions are entered for the calendar year. Advance payment in US dollars is required.


ISSN 1552-5775 Copyright © 2018 thepermanentejournal.org.

The Permanente Press. All Rights Reserved.