Association of Unplanned Reintubation with Higher Mortality in Old, Frail Patients: A National Surgical Quality-Improvement Program Analysis

Association of Unplanned Reintubation with Higher Mortality in Old, Frail Patients: A National Surgical Quality-Improvement Program Analysis

 

Efstathios Karamanos, MD; Nathan Schmoekel, DO; Dionne Blyden, MD; Anthony Falvo, DO; Ilan Rubinfeld, MD

Perm J 2016 Fall;20(4):16-017

https://doi.org/10.7812/TPP/16-017
E-pub: 10/12/2016

Abstract

Background: Unplanned postoperative reintubation increases the risk of mortality, but associated factors are unclear.
Objective: To elucidate factors associated with increased mortality risk in patients with unplanned postoperative reintubation.
Design: Retrospective study. Patients older than 40 years who underwent unplanned reintubation from 2005 to 2010 were identified using the American College of Surgeons National Surgical Quality Improvement Program database. Multiple regression models were used to examine the impact on mortality of factors that included the modified frailty index (mFI) we developed, American Society of Anesthesiologists (ASA) score, age decile, and days to reintubation.
Main Outcome Measure: Mortality.
Results: A total of 17,051 postoperative reintubations in adults were analyzed. Overall mortality was 29.4% (n = 5009). On postoperative day 1, 4434 patients were reintubated and 878 (19.8%) died. On postoperative day 7 and beyond, 6329 patients were reintubated and 2215 (35.0%) died. Increasing mFI resulted in increasing incidence of mortality (mFl of 0 = 20.5% mortality vs mFl of 0.37-0.45 = 41.7% mortality). As ASA score increased from 1 to 5, reintubation was associated with a mortality of 12.1% to 41.6%, respectively. Similarly, increasing age decile was associated with increasing incidence of mortality (40-49 years, 17.9% vs 80-89 years, 42.1%). After adjustment for confounding factors, mFI, ASA score, age decile, and increasing number of days to reintubation were independently and significantly associated with increased mortality in the study population.
Conclusion: Among patients who underwent unplanned reintubation, older and more frail patients had an increased risk of mortality.

INTRODUCTION

Unplanned reintubation is a measurable complication of surgical care that is associated with significant morbidity and mortality.1 Postsurgical physiologic deterioration or alterations of normal hormonal and metabolic physiology may contribute to respiratory failure and lead to eventual unplanned reintubation.2,3 In modern health care, quality is not only expected but is also reportable. Unplanned reintubation is an identifiable event in a patient’s postoperative course and serves as an outcome marker for quality improvement.

The population of Americans over the age of 65 years is projected to increase by 53.2% from the year 2003 to 2020.4 An increasing number of elderly patients will be undergoing surgery, leading to a projected 31% increase in general surgery workload.5 In recent years, a standardized measure of a patient’s physiologic reserve has been developed in an effort to predict postoperative morbidity and mortality.6,7 Frailty has been utilized to analyze multiple postoperative complications, including mortality.8,9 However, there is insufficient literature regarding the impact of unplanned reintubation in the elderly population.

We hypothesized that the use of the modified frailty index (mFI) in reintubated patients would be predictive of increased mortality. We further hypothesized that the time to reintubation and American Society of Anesthesiologists (ASA) score would also affect mortality.

Methods

This study used the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database. The NSQIP is a dataset used by hospitals nationally to help track areas of surgical performance for quality improvement.10 Trained nurse reviewers at each participating hospital are responsible for collecting the data, which encompasses approximately 136 variables per patient. These variables include patient demographics, preoperative risk factors, and postoperative mortality and complications within 30 days of surgery for patients undergoing major operations, such as unplanned reintubation. The NSQIP database defines unplanned reintubation as placement of an endotracheal tube and mechanical or assisted ventilation because of the onset of respiratory or cardiac failure manifested by severe respiratory distress, hypoxia, hypercarbia, or respiratory acidosis within 30 days of the operation.11

Patients age 40 years and older who underwent unplanned reintubation from 2005 to 2010 were included in our study. The following variables were extracted from the NSQIP database for each patient: age, sex, ASA classification, race, wound classification at the end of the surgery, whether or not the surgery was emergent, inpatient or outpatient status, surgical subspecialty performing the surgery, diabetes mellitus status, tobacco use and number of packs smoked per year, history of comorbidities, functional status, and preoperative laboratory values (hematocrit and albumin). The total operative time for each patient also was extracted. Additionally, weight and height were used to calculate the body mass index for each patient.

Modified Frailty Index

Frailty has been associated with increased adverse events and prolonged postoperative recovery in several studies.6,7,12 The Canadian Study of Health and Aging Frailty Index (CSHA-FI) is one index that has been developed to measure frailty. For this study, we calculated mFI by mapping the 70 variables from the CSHA-FI to the existing NSQIP preoperative variables, resulting in 11 matched variables, and then mapping these variables to the patients’ medical history. These 11 variables included nonindependent functional status; history of either chronic obstructive pulmonary disease or pneumonia; history of diabetes mellitus; hypertension requiring the use of medications; history of congestive heart failure; history of myocardial infarction; history of percutaneous coronary intervention, cardiac surgery, or angina; peripheral vascular disease or resting pain; transient ischemic attack or cerebrovascular accident without residual deficit; cerebrovascular accident with deficit; and impaired sensorium. A patient’s mFI was calculated as the proportion of variables present (“positive”) in a patient’s medical history from the total 11 variables. The primary outcome was mortality.

The mFI has been validated in previous studies. Park et al13 showed that the mFI correlates with postesophagectomy morbidity and mortality using the NSQIP database.

Statistical Analysis

To identify if age predicts mortality in patients undergoing unplanned reintubation, we divided the study population into groups by their age decile (40-49, 50-59, 60-69, 70-79, and 80-89 years). The incidence and odds ratio (OR) for mortality were calculated for each age decile.

To examine the impact of time to reintubation after surgery, we defined 4 different groups: Postoperative Days 0 to 1, 2 to 3, 4 to 6, and 7 and beyond. The postoperative complications were cross-tabulated with mortality and examined for differences using Student’s t-test or the c2 test as appropriate.

The study population was divided in 2 groups: patients who died and patients who survived. A univariate comparison was performed to identify differences between the 2 groups. Categorical variables were compared using the Pearson c2 or Fisher exact test as appropriate. Continuous variables were examined for normality of distribution using the Shapiro-Wilk test. Normally distributed variables were compared using the Student t-test, and nonnormally distributed variables were compared using the Mann-Whitney U test. Variables that were different at p < 0.05 were entered in a binary logistic regression to examine the impact on mortality of mFI, ASA, age decile, and days to reintubation. Adjusted ORs with 95% confidence interval (CI) were derived from the regression.

Results

A total of 1,334,886 patients were included in the NSQIP database from 2005 to 2010. Of those, 17,051 (1.3%) met our inclusion criteria and were analyzed. Of these 17,051 reintubated patients, 5009 had a documented death within 30 days of surgery. Therefore, the overall rate of postoperative mortality in patients requiring reintubation was 29.4%. Further analysis was performed to investigate the effect on mortality of patient age, ASA score, days to reintubation, and mFI. Patients who died were significantly more likely to be older compared with patients who survived (mean 71.4 years vs mean 67.4 years, p < 0.001), more likely to have undergone an emergent operation (35.2% vs 29.8%, p < 0.001), more likely to have type 1 diabetes (15.1% vs 13.0%, p < 0.001), and more likely to have an infected wound (19.8% vs 17.7%, p < 0.001). The mFI was significantly higher for patients who died (0.23 vs 0.20, p < 0.001). Details of patient clinical characteristics and demographics are presented in Table 1.

Table 2 shows the incidence of mortality for different study groups. The mortality rate was higher among patients who were reintubated later after their original surgery, compared with those reintubated sooner after their initial surgery. Patients who required reintubation on postoperative days 0 to 1 had a mortality rate of 19.8%; days 2 to 3, 28.4%; days 4 to 6, 32.9%; and day 7 and beyond, 35.0% (p < 0.001). When mortality was calculated for age, an associated increase in mortality with increase in age decile was observed. As patient age increased from the fourth through the eighth decile of age, the mortality rate increased from 17.9% to 42.1%. As seen in Table 1, the mean age of patients requiring reintubation who died was 71.4 years; however, Table 2 illustrates that mortality in patients requiring unplanned reintubation in the younger age deciles was significantly high (40-49 years, 17.9%; 50-59 years, 21.6%; p < 0.001). Similarly, Table 2 also illustrates that an increasing ASA score was associated with significantly higher mortality.

The impact of mFI on mortality after reintubation was examined using trend analysis and Mantel-Haenszel testing (Table 3). As mFI increased from 0 to 0.45, mortality rate increased from 20.5% to 41.0% (p < 0.001, linear R2 = 0.976).

After adjustment for differences between the 2 groups (dead vs alive), an increasing mFI was significantly associated with an increasing probability of dying (adjusted OR = 2.57, 95% CI = 1.94-3.40, p < 0.001; Table 4). Similarly, increased mortality was significantly associated with increasing ASA score (adjusted OR = 1.27, 95% CI = 1.20-1.35, adjusted p < 0.001), age decile (adjusted OR = 1.31, 95% CI = 1.27-1.35, p < 0.001), and days to reintubation (adjusted OR = 1.23, 95% CI = 1.20-1.27, p < 0.001).

Association of Unplanned Reintubation with Higher Mortality in Old, Frail Patients: A National Surgical Quality-Improvement Program Analysis

Association of Unplanned Reintubation with Higher Mortality in Old, Frail Patients: A National Surgical Quality-Improvement Program Analysis

Association of Unplanned Reintubation with Higher Mortality in Old, Frail Patients: A National Surgical Quality-Improvement Program Analysis

Discussion

This retrospective study of mortality in reintubated patients examined well-known risk factors such as age, ASA score, and time to reintubation. However, to the best of our knowledge, this is the first study specifically examining the impact of frailty on mortality in this population.

Unanticipated reintubation in the surgical patient population is a measurable event associated with significant morbidity. The present study suggests that the prognosis of reintubation depends on several factors including frailty, ASA class, age, and time to reintubation. In this study, the overall mortality of patients who required unplanned reintubation was exceedingly high (28.9%), which reflects the physiologic derangement driving respiratory failure.

The incidence and risk factors associated with reintubation have been previously examined.1,14,15 Snyder et al15 identified several risk factors for unplanned reintubation including severe chronic obstructive pulmonary disease, previous cardiac surgery, peripheral vascular disease, emergency procedure, dependent functional status, smoking within the past year, alcohol intake greater than 2 drinks per day, prior operation within the past 30 days, and transfer from an acute care hospital. Nafiu et al14 reported that among all patients requiring emergent reintubation after elective surgery, 3.3% were elderly. However, this classification reflected chronologic age only and not patients’ overall fitness and physiologic reserve.

For the present study, a frailty index modified from the CSHA-FI was developed using the 11 variables that are tracked in the NSQIP database. Multiple studies have shown that fewer variables may still yield an adequate assessment of a patient’s frailty. Rockwood et al16 studied the CSHA-FI and showed that using any 10 variables of that index resulted in comparable predictive value in frailty.

Respiratory failure within the first 72 hours after surgery has been related to hypoxemia and analgesic therapy.17,18 Ramachandran et al1 examined the incidence of early unplanned reintubation and found that one-half of all reintubations within a 30-day period occurred during the first 3 days, which was associated with a 9-fold increase in mortality. When adjusting for preoperative risk factors, these authors established a mortality rate of 9.7% to 30.6% in the first 3 days.1 These data, although similar to our findings, represent a patient population much more diverse than ours, because we focused on an older age group.

Several protective measures can be undertaken to potentially avoid the significant morbidity and mortality associated with unplanned reintubation. Early tracheostomy in patients who are anticipated to have a protracted respiratory failure has been advocated, but it remains controversial. The advantages include reduced rates of ventilator-associated pneumonia and decreased hospital length of stay. Several recent studies have tried to compare the outcomes between performing an early vs late tracheostomy, but the data remain controversial. The present study showed an incremental increase in the probability of adverse outcomes as the day to reintubation increased. It is possible that early tracheostomy in people who are anticipated to have a protracted ventilatory need and difficulty weaning off the ventilator would reduce the hypoxia and physiologic stress of an unplanned reintubation and would potentially result in fewer adverse events. It is possible that calculating a patient’s mFI will provide clinicians with a risk assessment tool regarding the probability of reintubation-associated mortality and will serve as a guide to patients and family counseling regarding early tracheostomy.

There are several limitations to this study. The first is the inability to know the details surrounding the indications for reintubation. This information may extend our knowledge of patients’ physiologic deterioration surrounding the event requiring reintubation. Second, NSQIP tracks reintubation as an event in a 30-day postoperative period, but it is not clear on which day a patient was initially extubated. Furthermore, NSQIP data include accidental extubations that require reintubation, and such events would potentially confound the results. The patient population requiring delayed extubation is likely more acutely ill and has an inherently higher mortality. This may be an area for future research. Another limitation to this study is that although NSQIP variables for preoperative risk assessment are collected prospectively, the mFI was applied retrospectively to these variables.

Conclusion

Despite the aforementioned limitations, this study was conducted using the NSQIP database, which is a robust nationwide database comprising data from diverse participating institutions and surgeons. Our overall mortality rate of 29.4% is consistent with prior studies that found 30-day mortality among reintubated patients to be 29.4%.15 We identified several patient variables that were predictive of mortality in reintubated patients: age, ASA score, time to reintubation, and frailty. Of these variables, frailty had the highest OR of 2.57.

This large, cross-sectional study of reintubated surgical patients found that despite the low overall incidence of postoperative reintubation, it is fraught with significant mortality, especially among older patient populations.

Disclosure Statement

The author(s) have no conflicts of interest to disclose.

Acknowledgements

Kathleen Louden, ELS, of Louden Health Communications provided editorial assistance.

How to Cite this Article

Karamanos E, Schmoekel N, Blyden D, Falvo A, Rubinfeld I. Association of unplanned reintubation with higher mortality in old, frail patients: A National Surgical Quality-Improvement Program analysis. Perm J 2016 Fall;20(4):16-017. DOI: https://doi.org/10.7812/TPP/16-017.

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